Experimental Study on Ginkgo Biloba Extract Against Carbon Tetrachloride-induced Chronic Liver Damage in Rats

AIM:To study the effects of Ginkgo Biloba extract(EGb) on carbon tetrachloride induced chronic liver damage in rats. METHOD:All rats were divided into four groups,and Yinxing Tianbao(EGb) and colchicin were given orally. Serum Hyaluronic acid(HA) and Laminin(LN) were detected by radioimmunoassay. Degrees of fibrosis were determined by histopathology under microscope. Hydroxyproline(Hyp) and the markers of liver function and oxidative stress were examined also. RESULT:The levels of serum ALb,ALT,AST,AKP in EGb groups were notably improved as compared with the model group. Serum HA,LN and Hyp of hepatic tissue in EGb groups were obviously lower than those of model group .HE stains showed that the degrees of liver fibrosis in EGb groups were slight than those of model and colchicin group. The markers of oxidative stress (SOD,MDA,GSH Px) were strikingly improved also in EGb groups. There was significant difference between the model group and EGb groups( P 0 05 or P 0 01). The rats in EGb groups were better than those of colchicines group. CONCLUSION:EGb is able to protect against carbon tetrachloride induced chronic liver damage,which may act through resisting oxidative stress.