Protective effects of the extract of ginkgo biloba on nonalcoholic steatohepatitis

Objective To investigate the protective effect of the extract of ginkgo biloba(EGB) on nonalcoholic steatohepatitis(NASH) in rats.Methods Wistar rats were randomly divided into three groups:normal group(N group,fed by normal diet),model group(M group,fed by high fat diet),and heal group [H group,fed by high fat diet and EGB 6 mg /(kg·d)].All rats were killed at the end of 12 weeks.Serum ALT,AST,HA,LN,PCⅢ,C-Ⅳ were detected,MDA,liver tissues were stained by HE and pathological grades were observed.SOD,MDA levels were measured.Results Compared with M group,hepatic damage of H group was significantly milder,liver function significantly improved.MDA level in liver decreased,while SOD increased.Serum levels of HA,LN,PCⅢ,C-Ⅳ as liver fibrosis markers decreased obviously(P 0.01).Conclusion EGB has the effects on inhibiting liver damage induced by NASH in rats.