Effects of Ginkgo Biloba Extract on Liver Protection for Type 2 Diabetic Rats

Type 2 diabetes was induced by feeding with high-sucrose-high-fat diet and injecting 25mg/kg streptozotocin. Rats were randomly divided into three groups: control, diabetic, diabetic simultaneously injected ip with Ginkgo biloba extract (EGb) for 8 wk. The treatment of EGb attenuated the development of hyperglycemia and hyperinsulinemia in type 2 diabetic rats. The serum levels of cholesterol, triglyceride as well as the activities of alanine aminotransferase, aspartate aminotransferase were significantly decreases in EGb-treated rats. The level of malondialdehyde were significantly increased in diabetic rats and decreased after EGb administration. Moreover, EGb markedly increased the activities of superoxide dismutase, catalase and glutathione peroxidase in liver. The results indicate that EGb has a protective effect on liver of type 2 diabetic rats, which may be related to decreases the accumulation of cholesterol, triglyceride in liver and its antioxidant property.