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2006•Unpublished venueRequires access

Influence of celecoxib on proliferation of human gastric cancer cell line

Ling Gui-qin, Xu Wang, Lin Wang, Xiaocui Li

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Abstract

Objective:To evaluate the effects and mechanisms of celecoxib on proliferation of human gastric cancer cells line.Methods: The proliferration of gastric cancer cell line was measured by using MTT assay.radioimmunoassay(RIA) was used to determine the influence of celexoxib on the level of 6-keto-PGF_(1α) in the supenatant of cultured gastric cancer cell.The effect of celecoxib on expression of VEGF was analyzed by using immunocellular chemical staining.Results: The growth of human gastric cancer cell line SGC7901 was inhibited by celecoxib.Treated with celecoxib,the production of 6-keto-PGF_(1α) in the supernatant of cultured cell was suppressed in a dose-dependent manner.Celecoxib also decreased the expression of VEGF and in a time-dependent manner.Conclusion: Celecoxib inhibites the growth of gastric cancer cell via suppression of 6-keto-PGF_(1α) and VEGF.

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What this paper is about

Objective:To evaluate the effects and mechanisms of celecoxib on proliferation of human gastric cancer cells line.Methods: The proliferration of gastric cancer cell line was measured by using MTT assay.radioimmunoassay(RIA) was used to determine the influence of celexoxib on the level of 6-keto-PGF_(1α) in the supenatant of cultured gastric cancer cell.The effect of celecoxib on expression of VEGF was analyzed by using immunocellular chemical staining.Results: The growth of human gastric cancer cell line SGC7901 was inhibited by celecoxib.Treated with celecoxib,the production of 6-keto-PGF_(1α) in the supernatant of cultured cell was suppressed in a dose-dependent manner.Celecoxib also decreased the expression of VEGF and in a time-dependent manner.Conclusion: Celecoxib inhibites the growth of gastric cancer cell via suppression of 6-keto-PGF_(1α) and VEGF.

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Available abstract

Objective:To evaluate the effects and mechanisms of celecoxib on proliferation of human gastric cancer cells line.Methods: The proliferration of gastric cancer cell line was measured by using MTT assay.radioimmunoassay(RIA) was used to determine the influence of celexoxib on the level of 6-keto-PGF_(1α) in the supenatant of cultured gastric cancer cell.The effect of celecoxib on expression of VEGF was analyzed by using immunocellular chemical staining.Results: The growth of human gastric cancer cell line SGC7901 was inhibited by celecoxib.Treated with celecoxib,the production of 6-keto-PGF_(1α) in the supernatant of cultured cell was suppressed in a dose-dependent manner.Celecoxib also decreased the expression of VEGF and in a time-dependent manner.Conclusion: Celecoxib inhibites the growth of gastric cancer cell via suppression of 6-keto-PGF_(1α) and VEGF.

Key concepts: Celecoxib, Radioimmunoassay, Cancer, Cell culture, Cell growth, Chemistry, Cancer cell, Cell

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