Significance of cyclin D1 and p27~(kip1) expression in renal cell carcinoma

Purpose To investigate the role of cyclin D1 and p27~(kip1) in the occurrence and development of coventional renal cell carcinoma(RCC).Methods RT-PCR was used to detect mRNA content of cyclin D1 in 25 cases of conventional RCC and 10 normal renal tissues distant from the tumor.Immunohistochemistry was used to investigate the expression of cyclin D1 and p27~(kip1) in pathological tissue sections of 76 conventional RCCs.The relationship between those index and clinicopathological parameters was analyzed statistically.Results In conventional RCC,the expression of cyclin D1 was higher than that of the control group.The higher cyclin D1 content was related to big tumor size(P0.05).The expression of p27~(kip1) was lower than that of the control group,and the lower p27~(kip1) was related to higher nuclear grade and TNM stage(P0.01).Conclusions The excessive expression of cyclin D1 and lower p27~(kip1) play an important role in the carcinogenesis of conventional RCC.The lower expression of p27~(kip1) may affect the progression of the tumors.The detection of p27~(kip1) may be as a reference marker in the prognosis evaluation of conventional RCC.