Expression of p~(27kip1) and cyclin D1 in renal cell carcinoma and their clinical significance

Objective:To evaluate the expressions of p27kip1 and cyclin D1 in renal cell carcinoma(RCC),and to explore the association between the biological characteristics of RCC and the expressions of p27kip1 and cyclin D1.Methods:The expressions of p27kip1 and cyclin D1 were detected by immunohistochemical S-P method in 53 cases of RCC and 6 normal renal tissues.Results:In normal renal tissues,p27kip1 was positively expressed and cyclin D1 was negatively expressed.There were significant differences in the positive expression rates of both p27kip1 and cyclin D1 in renal cell carcinomas of different pathological grades and clinical stages(p27Kip1:G1 to G2 70.00%,G3 to G4 27.27%,T1 to T2 70.83%,T3 to T4 20.69%;cyclin D1:G1 to G2 51.35%,G3 to G4 27.27%,T1 to T2 58.33%,T3 to T4 20.69%;all P 0.05).Conclusion:The expressions of p27kip1 and cyclin D1 are closely correlated with biological behavior of RCC.p27kip1 and cyclin D1 may play important roles in the occurrence and development of RCC.