THE ANALYSIS OF CLINICAL EFFICACY ON COMBINED INHALED TIOTROPIUM BROMIDE AND SALMETEROL / FLUTICASONE IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Objective: To study the clinical efficacy on combined inhaled tiotropium bromide and salmeterol / fluticasone in the treatment of chronic obstructive pulmonary disease( COPD). Methods: patients with moderate and severe COPD were randomly divided into two groups( n = 30 for each group),experimental group and control group. All patients were treated with routine anti-infection,oxygen inhalation,relieving phlegm and anti-asthma. The control group was given Salmeterol / fluticasone( 50 /500μg) twice daily,added tiotropium bromide 18 ug once daily to the observation group. Observe the chang of clinical symptoms、pulmonary function examination and blood gas analysis before treatment and after treatment eight weeks In two group. Result: There were no significant differences in the values of pulmonary function and arterial blood gas before treatment between two groups( P 0. 05). forced expiratory volume in 1 second( FEV1) 、FEV1/ FVC( forced vital capacity) 、FEV1% 、clinical symptoms and arterial blood gas index significantly improve after treatment eight weeks in patients of experimental group,Compared with the control group,there were significant differences in the values( P 0. 05).Conclusion: Combination therapy with tiotropium and Salmeterol /fluticason leads to better improved clinical symptoms、lung function and arterial blood gas as compared to salmeterol / fluticasion alone in the treatment of patients with moderate and severe COPD.