2006•Shenyang Yaoke Daxue xuebaoRequires access
Effects of Buyanghuanwu injection on hemorrheology and experimental thrombus in rats
Mu Xiaoshuo
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Abstract
Objective To study the effects of Buyanghuanwu(traditional Chinese medicines) injection on hemorrheology and experimental thrombus in rats.Methods The acute blood stasis model was made by immersing the rats into ice-water bath and injecting adrenalin hydrochloride(i.p.),and the hemorrheology was measured;the experimental thrombus model was established in rats by artery-vein bypass method in order to observe the effect of Buyanghuanwu injection on the formation of arterial thrombus;the effect of Buyanghuanwu injection on platelet aggregation induced by ADP in rabbits in vitro was studed.Results Buyanghuanwu injection could significantly decrease the viscosities of the whole blood and plasma,inhibit the formation of experimental thrombus in rats,and markedly reduce the ADP-induced platelet aggregation in rabbits in vitro.Conclusions Buyanghuanwu injection has the notable activity of anti-thrombosis,it can reduce the rate of platelet aggregation in rabbits and improve the hemorrheological parameters in acute blood stasis rats.