2005•Zhongguo shiyan fangjixue zazhiRequires access

Effects of Quyuningtong Paster on Hemorheological Parameters, PlateletAggregation and Thrombus Formation in Acute Blood Stasis Rats

Bin Wei

Abstract

Objective:To investigate the effects of Quyuningtong Paster(QYNTP) on hemorheological parameters, platelet aggregation and thrombus formation in vitro in acute blood stasis rats. Methods:The acute blood stasis model in rats were established with subcutaneous injection of high-dose adrenaline hydrochloride and being socked in ice-water. The effects of QUNTP on the indexes of hemorheology, platelet aggregation and thrombus formation in vitro in acute blood stasis model rats were observed. Results: The QYNTP(0.3g/kg、0.9g/kg、1.8g/kg) could not only significantly reduce the viscosity of whole blood, viscosity of plasma, content of fibrinogen, packed volume of erythrocyte, slow down the erythrocyte sedimentation rate and shorten the erythrocyte electrophoresis time, it also remarkably inhibit the platelet aggregation and thrombus formation in vitro (respectively P0.05 or 0.01). Conclusion:QYNTP could obviously ameliorate the hemorheological parameters, inhibit platelet aggregation and thrombus formation in acute blood stasis rats.

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Key concepts: Hemorheology, Blood stasis, Thrombus, Erythrocyte aggregation, Blood viscosity, Fibrinogen, Platelet aggregation, Platelet