2011•Journal of Shenyang Medical CollegeRequires access
Effects of Xuemaishu Granules on the Formation of Thrombus and Hemorheology in Rats
Wang Lin
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Abstract
Objective:To observe the effects of Xuemaishu Granules on the formation of thrombus and hemorheology in rats.Methods:The rat thrombus modle in vitro was made by artery-vein loop method.The acute blood stasis model was made by immersing ice-water into the rat with hypodermic injection of adrenalin hydrochloride and then treated with Xuemaishu Granules at 4,8,16 g/kg to observe the effects of the drug on formation of thrombus and the parameters of hemorheology. Results:At the medium or high dose,Xuemaishu Granules could significantly inhibit the formation of experimental thrombus in rats,compared with that in the control group(P0.01)and reduce the viscosities of the whole blood and plasma,compared with that in the blood stasis mode group(P0.01).Conclusion:Xuemaishu Granules show activity of anti-thrombosis and can improve the hemorheological parameters in acute blood stasis rats.