Establishment of type 1 diabetes rat model induced by streptozotocin

Objective To establish an ideal type 1 diabetes mellitus SD rats model.Methods SD rats were injected intraperitoneally with 65 mg/kg streptozotocin once to induce hyperglycemia.Results One week after induced by streptozotocin(STZ),the blood glucose of the experimental group were higher than 16.7 mmol/L.During the 8 weeks observation,the blood glucose of the experimental group were stably higher than 16.7 mmol/L.Morphological investigation on pancreas showed the reduction of islets, loss of β cells in the experimental group.Conclusion The experiment provided an ideal type 1 diabetes mellitus SD rats model.