Efficacy and Mechanism of Shuangbai Zhiyang Lotion on Chronic Hand Eczema

Objective To observe the efficacy of Shuangbai Zhiyang lotion on chronic hand eczema,and to explore its mechanism.Methods A total of 60 patients with chronic hand eczema in the observation were randomly divided into two groups with a random number table,the observation group and the control group.The outcome of their symptoms were observed in follow-up three months,and then compared the first relapse time between these two groups.CD3,CD4 and CD8 lymphocytes of patients were detected by flow cytometry before and after treatment.Results 13 cases in the observation group had been cured after treatment,and total effective rate was 83.3%.And five cases in the control group had been cured,and total effective rate was 53.3%.By Ridit analysis,curative effect of observation group was better than that of control group(P=0.007 5,P0.01).After treatment,four kinds of T-lymphocyte subsets could be detected.Compared to the mean before treatment,CD3+ and CD4+ was significantly increased in the treatment group,but it was not increased obviously in the control group.After treatment,the differences of CD3+ and CD4+ were significant.Conclusion Shuangbai Zhiyang lotion can eliminate symptoms quickly,and it can prolong or prevent the recurrence of eczema significantly.Long-term effect is good.Its mechanism may be related to the effect on immune function and inhibiting T lymphocyte activation.