Polymorphism of lipoprotein lipase Hind III gene in Shanghai Chinese Han cerebral hemorrhage patients

Objective To study the correlation between polymorphism of lipoprotein lipase(LPL) HindⅢ gene and cerebral hemorrhage.Methods One hundred and twenty cerebral hemorrhage patients served as a cerebral hemorrhage group and 147healthy subjects served as a control group in this study.Polymorphonism of LPL HindⅢ gene was detected in the two groups.Their blood lipid and blood glucose levels were measured.Results The detection rate of T and G allelic gene was 90.8%and 9.2%in cerebral hemorrhage group and 82.3%and 17.7%in control group.The detection rate of G allelic gene and GG genotype was significantly lower whereas the serum levels of TG,LDL-C,fasting blood glucose,and the systolic and diastolic pressure were significantly higher in cerebral hemorrhage group than in control group(P0.05,P0.01).The serum TG level was significantly higher in patients carrying the TT genotype than in those carrying the GG+TG genotype(P0.05).Multivariate logistic regression analysis showed that the HindⅢ gene polymorphonism was related with cerebral hemorrhage after adjustment for age,hypertension and hyperglycemia(OR=0.392,95%CI:0.191-0.805,P=0.011).Conclusion LPL HindⅢ gene polymorphonism is related with cerebral hemorrhage.The LPL HindⅢ G allelic gene mutation may be a protective factor for cerebral hemorrhage.