Prevention of bleeding from stress ulceration after severe craniocerebral injures

Objective To study the prevention of bleeding from stress ulceration afrer severe craniocerebral injures.Methods One hundred and sixty-nine patients with severe craniocerebral injures were divided randomly into 4 groups,and were treated respectively by Omeprazole,Somatostatin,Omeprazole plus Somatostatin and without special drugs.Then,the patients in each group were classified into the bleeding group and the non-bleeding group.Their different time pHis were determined with tonometry.The different time pH of gastric juice were also monitored.Results The bleeding preventing effects by Omeprazole plus Somatostatin was more effective as compared to other groups,meanwhile it did not cause the pH value of gastric juice to decrease further.On admission,the pHi was not significantly different between the non-bleeding group and the bleeding group,but the differences between two groups at 12h,24h,and on 3rd,5th day,the 7th day after admission were significantly marked,pHi in the bleeding group was statistically lower than that of non-bleeding group,meanwhile the pH values of gastric juice were not significantly different between the 2 groups during each therapeutic period.ConclusionpHi was predictive for bleeding from stress ulceration after severe craniocerebral injures.