Tube feeding with the mixture Of anisodamine and aluminium hydroxide gel to prevent and cure the upper digestive tract ulcer bleeding resulted from severe brain damage

Objective To study the effect of early administration of a mixture of Anisodamine and A-luminium hydroxide gel via nasal gastric tube in preventing in stress - induced digestive tract bleeding in patients with severe brain damage. Method One thousand one hundred and thirteen patients with severe brain damage were divided into three groups: control group 410 cases without any measures to prevent digestive tract bleeding within 72 hours after injury, treatment group A 540 cases when given cimetidine, ranitidine and Losec by intravenous injection or nasal feeding. Group B 240 cases who received nasal feeding of aniso-damine and Aluminium Hydroxide gel mixture. The incidence of bleeding in each group was recorded . Results The incidence of the upper digestive tract bleeding in group B is 1.25% , compared with that of control group( x2 = 90. 13, P 0. 01) , while with that of group A ( x2 = 12. 32, P 0. 01) , the incidence of bleeding in group B is distinctively lower than that in other two groups. The number of the patients requiring transfusion and the amount of the blood needed as well as the mortality in group B decline simultaneously. The symptom of reflex of gastroenteric contents possibly caused by tube feeding was not found in all these groups. Comparing group A with control group:x2 =38. 36,P0.01 and the incidence of bleeding in group A also has a significant decline. Conclusion To prevent the stress induced upper GI bleeding in patients with severe brain damage should not be limited in raising the pH value of the gastric juice only but should also be focused on improving the blood irrigation to the gastric mucosa, in order to ameliorate its acute pathological changes. The general clinical effective rate of tube feeding with anisodamine and aluminium hydroxide gel mixture reaches 98. 75%. The ulcer inhibiting rate in animal experiment has been reported to be 79. 1%. It has a significant practical value in the prevention and cure of the digestive bleeding in those patients suffered from severe brain damage.