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2001•Chinese Journal of Oral & Maxillofacial SurgeryRequires access

THE IMMUNOHISTOCHEMICAL EXPRESSION OF CD44s AND CD44v6 IN ORAL SQUAMOUS CELL CARCINOMAS

Cheng Xing-ming

Open publisher page 1 citations

Abstract

Objective To investigate the expression of CD44s and CD44v6 in human oral squamous cell carcinoma (OSCC) and its relationship with the development and matastasis of OSCC. Methods 26 cases of OSCC and their 11 metastatic lymph nodes were studied by immunohistochemical S-P method. Results There was a significant less expression of CD44s and CD44v6 in the OSCC compared to the normal oral mucosa (P0.05, P0.001 respectively). There was a significant relationship between CD44v6 expression and histological differential. OSCC with metastatic lymph node displayed significant down-regulation of CD44v6 than those without. (P0.001).Conclusions (1) Down-regulation of CD44s and CD44v6 may contribute to the development of OSCCs. (2) It is proposed that down-regulation of CD44v6 may play a role in the metastasis of OSCC and may be used as a useful diagnostic tool to determine the metastatic potential of OSCC to lymph node.

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What this paper is about

Objective To investigate the expression of CD44s and CD44v6 in human oral squamous cell carcinoma (OSCC) and its relationship with the development and matastasis of OSCC. Methods 26 cases of OSCC and their 11 metastatic lymph nodes were studied by immunohistochemical S-P method. Results There was a significant less expression of CD44s and CD44v6 in the OSCC compared to the normal oral mucosa (P0.05, P0.001 respectively). There was a significant relationship between CD44v6 expression and histological differential. OSCC with metastatic lymph node displayed significant down-regulation of CD44v6 than those without. (P0.001).Conclusions (1) Down-regulation of CD44s and CD44v6 may contribute to the development of OSCCs. (2) It is proposed that down-regulation of CD44v6 may play a role in the metastasis of OSCC and may be used as a useful diagnostic tool to determine the metastatic potential of OSCC to lymph node.

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Available abstract

Objective To investigate the expression of CD44s and CD44v6 in human oral squamous cell carcinoma (OSCC) and its relationship with the development and matastasis of OSCC. Methods 26 cases of OSCC and their 11 metastatic lymph nodes were studied by immunohistochemical S-P method. Results There was a significant less expression of CD44s and CD44v6 in the OSCC compared to the normal oral mucosa (P0.05, P0.001 respectively). There was a significant relationship between CD44v6 expression and histological differential. OSCC with metastatic lymph node displayed significant down-regulation of CD44v6 than those without. (P0.001).Conclusions (1) Down-regulation of CD44s and CD44v6 may contribute to the development of OSCCs. (2) It is proposed that down-regulation of CD44v6 may play a role in the metastasis of OSCC and may be used as a useful diagnostic tool to determine the metastatic potential of OSCC to lymph node.

Key concepts: Immunohistochemistry, Lymph node metastasis, Pathology, Basal cell, Lymph node, Medicine, Metastasis, Lymph

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