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2006•Chinese Archives of Otolaryngology-head and Neck SurgeryRequires access

Investigation of GR-α m RNA quantitative expression in nasal polyps

Bin Hu

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Abstract

OBJECTIVE To detect the expression of the Glucocorticoid receptor-α(GR-α)mRNA in nasal polyp and normal nasal mucosa and investigate the route of nasal drug administration in patients of nasal polyp. METHODS The expression of GR-αmRNA in 101 samples of nasal polyps and 31samples of normal nasal mucosa was examined by using Fluorescent quantitative PCR .RESULTS The level of GR-αmRNA in normal nasal mucosa(135.4± 5.25)×104 copy /μg were significantly higher than that in nasal polyps(23.5±12.1)×104 copy/μg . CONCLUSION Because of the low expression of GR-αmRNA in nasal polyps,the route of nasal drug administration in patients with nasal polyps may be in the part of normal mucosa,not in the mucosa of nasal polyps of the nasal cavity.

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OBJECTIVE To detect the expression of the Glucocorticoid receptor-α(GR-α)mRNA in nasal polyp and normal nasal mucosa and investigate the route of nasal drug administration in patients of nasal polyp. METHODS The expression of GR-αmRNA in 101 samples of nasal polyps and 31samples of normal nasal mucosa was examined by using Fluorescent quantitative PCR .RESULTS The level of GR-αmRNA in normal nasal mucosa(135.4± 5.25)×104 copy /μg were significantly higher than that in nasal polyps(23.5±12.1)×104 copy/μg . CONCLUSION Because of the low expression of GR-αmRNA in nasal polyps,the route of nasal drug administration in patients with nasal polyps may be in the part of normal mucosa,not in the mucosa of nasal polyps of the nasal cavity.

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Available abstract

OBJECTIVE To detect the expression of the Glucocorticoid receptor-α(GR-α)mRNA in nasal polyp and normal nasal mucosa and investigate the route of nasal drug administration in patients of nasal polyp. METHODS The expression of GR-αmRNA in 101 samples of nasal polyps and 31samples of normal nasal mucosa was examined by using Fluorescent quantitative PCR .RESULTS The level of GR-αmRNA in normal nasal mucosa(135.4± 5.25)×104 copy /μg were significantly higher than that in nasal polyps(23.5±12.1)×104 copy/μg . CONCLUSION Because of the low expression of GR-αmRNA in nasal polyps,the route of nasal drug administration in patients with nasal polyps may be in the part of normal mucosa,not in the mucosa of nasal polyps of the nasal cavity.

Key concepts: Mucous membrane of nose, Nasal polyps, Nasal cavity, Medicine, Glucocorticoid receptor, Messenger RNA, Real-time polymerase chain reaction, Nasal administration

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