Effect of Long-term Family Noninvasive Positive Pressure Ventilation in the Treatment of Stable Chronic Obstructive Pulmonary Disease with Type II Respiratory Failure

Objective To investigate the effect of long- term family noninvasive positive pressure ventilation( NPPV)in the treatment of stable chronic obstructive pulmonary disease with type Ⅱ respiratory failure. Methods 50 stable COPD patients with type Ⅱ respiratory failure treated in our hospital from May 2009 to May 2010 were randomly divided into treatment group and control group,25 cases in each. The treatment group received conventional therapy + family NPPV,the control group received conventional therapy + family oxygen therapy. Both groups were followed- up for 2- year after discharged,the 6min walking distance,arterial blood gas analysis,pulmonary function,accessory muscle score,quality of life and adverse reactions of two groups were compared at discharge and 2 years after discharge,re- admission times recorded. Results There was no statistically significance difference in 6 min walking distance,forced vital capacity( FVC),1s forced expiratory volume( FEV1),PaCO2,PaO2,auxiliary ventilator score and St. George 's Respiratory Questionnaire( SGRQ) score between the two groups were compared at discharge( P 0. 05); 2 years after discharge,the 6 min walking distance,FVC,FEV1and PaO2of treatment group were higher than those of control group( P 0. 05),PaCO2,auxiliary ventilator score,SGRQ scores and re-admission times were lower than those of control group( P 0. 05). Conclusion Long- term family NPPV is effective in the treatment of stable COPD with type Ⅱ respiratory failure,which can improve respiratory muscle strength recovery and contractile function,correct hypoxia and hypercapnia,delay lung failure,improve patients' quality of life.