The treatment of long term noninvasive positive pressure ventilation in patients with stable severe chronic obstructive pulmonary disease

Objective To explore the treatment effect of long term home noninvasive positive pressure ventilation(NPPV)in stable severe patients with chronic obstructive pulmonary disease(COPD).Methods40 cases of in-hospital treatment severe COPD after stable period were divided into treatment group(conventional treatment+NPPV)and control group(conventional treatment),with 20 cases in each group.The lung function test,arterial blood gases,6MWD,mortality and hospitalization rates were recorded before the treatment and 2 years after the treatment.ResultsThe treatment group and control group of age,sex,height,weight,arterial PaO2 and PaCO2,forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),6MWD,the number of in-patient per year were all comparable(t=0.42,3.84,0.29,0.42,0.29,0.32,1.01,1.65,0.38,0.23,P0.05).5 cases in the treatment group and 8 cases in the control group were dead after 2 years,and the difference between the two groups was not significant(χ2=3.84,P0.05).The measures of PaO2,PaCO2,6MWD,the number of in-patient per year between the groups were statistically significant difference(t=0.29,7.25,0.32,6.26,1.01,6.2,.65,3.44,0.38,3.02,0.23,7.62,P0.05).ConclusionLong-term use of home noninvasive positive ventilation patients with stable severe COPD is effective and safe.