Contrast study of trimetazidine and coenzyme Q_(10) for stable exertional angina

Objective: To compare the effect of trimetazidine and coenzyme Q10 for treatment of patients with stable exertional angina.Methods: 108 patients with stable exertional angina were randomly divided into trimetazidine group (n=54) and coenzyme Q10 group(n=54).Two group were combined with any one of nitrates,β blockers and calcium antagonists to aspirin.The trimetazidine group were given trimetazidine 20 mg,po,tid for 12 weeks While the coenzyme Q10 group were received coenzyme Q10 20 mg,po tid for 12 weeks.Clinical treatment effective indexes were observed.Results: Total efficacy rates in relieving angina symptom and improving the ECG parameters of the trimetazidine group were 94.4% and 68.5%, respectivealy.The same parameters of coenzyme Q10 group were 88.9% and 59.3% respetively.The above parameters of trimetazidine group were remarkably better than coenzyme Q10 group (P0.05).Conclusion: The efficacies of trimetazidine are better than coenzyme Q10 for stable exertional angina.