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Antioxidant effects of L-carnitine on aged mice

Shuping Zhang

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Abstract

Objective:To study the antioxidant effects of L-carnitine on aged mice,and to investigate its effect on the levels of SOD,GSH-PX,CAT and MDA in serum and brain tissue.Methods:The mice were divided into 5 groups:young control group,aged control group and L-carnitine treated aged mice groups(0.25,0.5,1.0 g·kg-1·d-1).The mice in L-carnitine treatment groups were orally administered L-carnitine for 4 weeks.The mice were sacrificed,and then the levels of SOD,GSH-Px,CAT activity,and also the MDA content in serum and brain tissue were examined using kit.Results:Compared with the aged control group,L-carnitine could significantly enhance the SOD,GSH-Px and CAT activity in serum and brain tissue,and reduce the MDA content dose-dependently.Conclusions:The results indicate that L-carnitine has antioxidant effects on aged mice.

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What this paper is about

Objective:To study the antioxidant effects of L-carnitine on aged mice,and to investigate its effect on the levels of SOD,GSH-PX,CAT and MDA in serum and brain tissue.Methods:The mice were divided into 5 groups:young control group,aged control group and L-carnitine treated aged mice groups(0.25,0.5,1.0 g·kg-1·d-1).The mice in L-carnitine treatment groups were orally administered L-carnitine for 4 weeks.The mice were sacrificed,and then the levels of SOD,GSH-Px,CAT activity,and also the MDA content in serum and brain tissue were examined using kit.Results:Compared with the aged control group,L-carnitine could significantly enhance the SOD,GSH-Px and CAT activity in serum and brain tissue,and reduce the MDA content dose-dependently.Conclusions:The results indicate that L-carnitine has antioxidant effects on aged mice.

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Available abstract

Objective:To study the antioxidant effects of L-carnitine on aged mice,and to investigate its effect on the levels of SOD,GSH-PX,CAT and MDA in serum and brain tissue.Methods:The mice were divided into 5 groups:young control group,aged control group and L-carnitine treated aged mice groups(0.25,0.5,1.0 g·kg-1·d-1).The mice in L-carnitine treatment groups were orally administered L-carnitine for 4 weeks.The mice were sacrificed,and then the levels of SOD,GSH-Px,CAT activity,and also the MDA content in serum and brain tissue were examined using kit.Results:Compared with the aged control group,L-carnitine could significantly enhance the SOD,GSH-Px and CAT activity in serum and brain tissue,and reduce the MDA content dose-dependently.Conclusions:The results indicate that L-carnitine has antioxidant effects on aged mice.

Key concepts: Carnitine, Antioxidant, Brain tissue, Endocrinology, Antioxidant capacity, Glutathione, Internal medicine, Chemistry

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