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2004•Chinese Journal of Hospital PharmacyRequires access

Determination of gliclazide sustained-release tablets by HPLC

Hong Ding

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Abstract

OBJECTIVE To establish a method for determining the content of gliclazide sustained-release tablets by HPLC. METHODS A C_ 18 column was used and the mobile phase consisted of methanol-sodium dihydrogen phosphate solution (64∶36).The detection wavelength was 229 nm. RESULTS The linear range of calibration curve of gliclazide was 8.016 ～ 12.024 mg·L -1 ( r = 0.9992 ), and the average recovery was 99.5% , RSD= 0.7% ( n =6). CONCLUSION The method is simple,rapid and accurate. It can be used for determining the content of gliclazide sustained-release tablets.

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OBJECTIVE To establish a method for determining the content of gliclazide sustained-release tablets by HPLC. METHODS A C_ 18 column was used and the mobile phase consisted of methanol-sodium dihydrogen phosphate solution (64∶36).The detection wavelength was 229 nm. RESULTS The linear range of calibration curve of gliclazide was 8.016 ～ 12.024 mg·L -1 ( r = 0.9992 ), and the average recovery was 99.5% , RSD= 0.7% ( n =6). CONCLUSION The method is simple,rapid and accurate. It can be used for determining the content of gliclazide sustained-release tablets.

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Available abstract

OBJECTIVE To establish a method for determining the content of gliclazide sustained-release tablets by HPLC. METHODS A C_ 18 column was used and the mobile phase consisted of methanol-sodium dihydrogen phosphate solution (64∶36).The detection wavelength was 229 nm. RESULTS The linear range of calibration curve of gliclazide was 8.016 ～ 12.024 mg·L -1 ( r = 0.9992 ), and the average recovery was 99.5% , RSD= 0.7% ( n =6). CONCLUSION The method is simple,rapid and accurate. It can be used for determining the content of gliclazide sustained-release tablets.

Key concepts: Gliclazide, Chromatography, Calibration curve, High-performance liquid chromatography, Chemistry, Methanol, Detection limit, Medicine

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