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2010•China Modern MedicineRequires access

Determination of gliclazide modified release tablets by RP-HPLC

Luo Hai

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Abstract

Objective: To establish a method for determination of Gliclazide Modified Release tablets by RP-HPLC. Methods: The chromatographic column was Hypersil ODS C18 and the mobile phase consisted of methanol-water (60:40). The detection wavelength was 228nm and the flow rate was 1.0 ml/min,using glipizide as internal standard. Results: There was a good linear relationship when the sample size was within the range of 4～64 μg/ml (r=0.999 8). The average recovery was 99.83%(RSD=1.04%). Conclusion: The method is convenient, fast, reproducible, which can be used for the content determination of gliclazide modified release tablets.

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What this paper is about

Objective: To establish a method for determination of Gliclazide Modified Release tablets by RP-HPLC. Methods: The chromatographic column was Hypersil ODS C18 and the mobile phase consisted of methanol-water (60:40). The detection wavelength was 228nm and the flow rate was 1.0 ml/min,using glipizide as internal standard. Results: There was a good linear relationship when the sample size was within the range of 4～64 μg/ml (r=0.999 8). The average recovery was 99.83%(RSD=1.04%). Conclusion: The method is convenient, fast, reproducible, which can be used for the content determination of gliclazide modified release tablets.

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Available abstract

Objective: To establish a method for determination of Gliclazide Modified Release tablets by RP-HPLC. Methods: The chromatographic column was Hypersil ODS C18 and the mobile phase consisted of methanol-water (60:40). The detection wavelength was 228nm and the flow rate was 1.0 ml/min,using glipizide as internal standard. Results: There was a good linear relationship when the sample size was within the range of 4～64 μg/ml (r=0.999 8). The average recovery was 99.83%(RSD=1.04%). Conclusion: The method is convenient, fast, reproducible, which can be used for the content determination of gliclazide modified release tablets.

Key concepts: Gliclazide, Glipizide, Medicine, Chromatography, High-performance liquid chromatography, Linear relationship, Diabetes mellitus, Chemistry

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