2001•Acta Academiae Medicinae JiangxiRequires access
Biological Effects of Tetrandrine on Scar Fibroblasts
Liu De
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Abstract
Objective: To investigate the biological effects of tetrandrine on scar fibroblasts and to evaluate the role of tetrandrine in the treatment of scar. Methods: Using the cultured fibroblasts derived from human scar and the experimental scars in rabbits as models, the effects of tetrandrine on biological properties of scars and fibroblasts were observed. Results: In vitro, the incorporation rates of 3H-TdR and 3H-proline in cultured fibroblasts were lower in tetrandrine groups with a concentration-related manner. Fibroblasts in scar tissue in rabbits treated with tetrandrine displayed fewer rough endoplasmic reticulum under the transmission electron microscope, which suggested an inactive status of protein synthesis and secretion. Conclusions: Tetrandrine could inhibit not only the proliferation of scar fibroblasts, but also the synthesis and secretion of collagen.