ScholarLens Back to search
2002•Unpublished venueRequires access

STUDIES ON THE BIOAVAILABILITY OF COMPOUND THEOPHYLLINE-KETOFEN SUSTAINED-RELEASE TABLET IN DOGS

Hong Zheng

Open publisher page 0 citations

Abstract

OBJECTIVE 12 dogs were divided into two groups for the study of the bioavailability of componund theophylline-ketofen sustained-release tablet(CTKSRT) vs theophylline controled-release tablet(TCRT) as reference drug.METHODS Both drugs were administered 200 mg orally.The blood plasma concentration of theophylline were assayed by HPLC columm switching method.The pharmacokinetic parameters of CTKRST and TCRT were calculated by 3p87 program.RESULTS There were no significant difference between the pharmacokinetics parameter of CTKRST and TCRT.AUC:236±34.80 and 207.88±31.80 mg·L -1·h -1;C max: 12.99±3.11 and 11.55±2.83 mg·L -1;T max:6.88±0.98 and 7.00±0.89 h,respectively.The relative bioavailability of CTKSRT was 113.76%.CONCLUSION The two formulations both are extended release and with bioequivalent in dogs administered orally.

About this research paper

What this paper is about

OBJECTIVE 12 dogs were divided into two groups for the study of the bioavailability of componund theophylline-ketofen sustained-release tablet(CTKSRT) vs theophylline controled-release tablet(TCRT) as reference drug.METHODS Both drugs were administered 200 mg orally.The blood plasma concentration of theophylline were assayed by HPLC columm switching method.The pharmacokinetic parameters of CTKRST and TCRT were calculated by 3p87 program.RESULTS There were no significant difference between the pharmacokinetics parameter of CTKRST and TCRT.AUC:236±34.80 and 207.88±31.80 mg·L -1·h -1;C max: 12.99±3.11 and 11.55±2.83 mg·L -1;T max:6.88±0.98 and 7.00±0.89 h,respectively.The relative bioavailability of CTKSRT was 113.76%.CONCLUSION The two formulations both are extended release and with bioequivalent in dogs administered orally.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

OBJECTIVE 12 dogs were divided into two groups for the study of the bioavailability of componund theophylline-ketofen sustained-release tablet(CTKSRT) vs theophylline controled-release tablet(TCRT) as reference drug.METHODS Both drugs were administered 200 mg orally.The blood plasma concentration of theophylline were assayed by HPLC columm switching method.The pharmacokinetic parameters of CTKRST and TCRT were calculated by 3p87 program.RESULTS There were no significant difference between the pharmacokinetics parameter of CTKRST and TCRT.AUC:236±34.80 and 207.88±31.80 mg·L -1·h -1;C max: 12.99±3.11 and 11.55±2.83 mg·L -1;T max:6.88±0.98 and 7.00±0.89 h,respectively.The relative bioavailability of CTKSRT was 113.76%.CONCLUSION The two formulations both are extended release and with bioequivalent in dogs administered orally.

Key concepts: Theophylline, Bioavailability, Bioequivalence, Pharmacokinetics, Chemistry, Pharmacology, Plasma concentration, Chromatography

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
STUDIES ON THE BIOAVAILABILITY OF COMPOUND THEOPHYLLINE-KETOFEN SUSTAINED-RELEASE TABLET IN DOGS — Research Paper | ScholarLens