Evaluation of dezocine combined with flurbiprofen axetil or fentanyl for postoperative analgesia in patients undergoing thoracic surgery

Objective To evaluate the efficacy and safety of dezocine combined with flurbiprofen axetil or fentanyl for postoperative patient-controlled intravenous analgesia (PCIA)in patients undergoing thoracic surgery.Methods One hundred and twenty ASA Ⅰ or Ⅱ patients scheduled for elective thoracic surgery were randomly divided into three groups according to different PCIA formula: group A received fentany1 0.5 mg plus dezocine 30 mg;group B received dezocine 30 mg plus flurbiprofen axetil 200 mg; group C received fentany1 0.5 mg plus flurbiprofen axetil 200 mg.Tropisetron 6mg was also added identically in all groups. Total PCIA volume was 100 saline with loading volume 2 ml,background volume 2 ml/h,bolus dose 0.5 ml,and lockout time was set 15 min. The VAS, Prince-Henry and Ramsay sedation scale were recorded 2,4,8,24,48 h after surgery.Total pressing times 24 h postoperatively and the adverse effects were also recorded.Results Prince-Henry scale and VAS score 2h,4h after surgery and total PCIA pressing times were higher in group A than group B and C without difference between group B and C(P0.05). The Ramsay sedation scale was lower 2h postoperatively but higher 4,8,and 24 hours after surgery in group A than in group B and C(P0.05).Conclusion Dezocine combined with flurbiprofen axetil for postoperative patient-controlled intravenous analgesia (PCIA)is effective and safe than dezocine combined with fentanyl in patients undergoing thoracic surgery.