A clinical study of short-term Xuebijing injection (血必净注射液) on treatment of patients with acute exacerbation of chronic obstructive pulmonary disease

Objective To investigate the therapeutic effect of short-term Xuebijing injection (血必净注射液) on treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Sixty-two patients with AECOPD were enrolled to participate in this study, which was randomly divided into control group (n=30) and treatment group (n=32). The conventional western treatment of COPD was adopted in the control group; based on the similar conventional western therapy in the control group Xuebijing injection was added in the treatment group. Blood gas analysis, blood rheology, blood cell count and C reactive protein were monitored before and 3 days after treatment. The hospital stay time was recorded. Results After patients were treated, in the treatment group the values of pH, partial pressure of oxygen (PaO2), saturation of arterial blood oxygen (SaO2), hematocrit, whole blood viscosity of low and high shear rates and blood cells were improved obviously compared with those before treatment (P0.05 or P0.01). The change of PaO2, SaO2, whole blood viscosity of low and high shear rates and blood cells in the treatment group before and after the treatment were more significant than those in the control group, and the difference between the two groups were significant (all P0.05). The period of patient stay in the hospital in treatment group was markedly shorter than that in the control group, the difference being statistically significant (18.5±1.5) days vs. (23.4±1.9) days, P0.05. Conclusion These data suggest that the combined use of western conventional therapy and short-term Xuebijing injection elevate the therapeutic effect for treatment of patients with AECOPD.