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[The effect of biphenyl dimethyl dicarboxylate (DDB) on the fluidity of human erythrocyte membrane].

L Chen, W W Chen

Abstract

This paper deals with the effects of DDB on human RBC membrane fluidity as reflected by changes in the phase transition temperature and microviscosity monitored by ANS, NPN and DPH. The results showed that DDB decreased the fluidity of the shallow layer (ANS as probe), but increased the fluidity of the middle layer (NPN as probe) and deeper layer (DPH as probe). In addition, the drug was found to inhibit the hemolysis induced by MDA.

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Available abstract

Key concepts: Microviscosity, Membrane fluidity, Chemistry, Hemolysis, Membrane, Biphenyl, Biophysics, Erythrocyte membrane