2004•Chinese Journal of Gastroenterology and HepatologyRequires access
Relationship between hTERT protein expression and Bcl-2 protein expression in human gastric carcinoma and its precancerous lesions
He Juntang
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Abstract
Objective To study the expression of hTERT protein expression and Bcl-2 protein expression in human gastric carcinoma and its precancerous lesions, and explore the relationship between hTERT protein expression and Bcl-2 protein expression. Methods Using immunohistochemical method to study the frequencies of hTERT protein expression and Bcl 2 protein expression in 45 chronic gastritis and 19 gastric carcinoma. Results It takes on an increased tendency that the positive frequency of hTERT protein expression in chronic atrophic gastritis, intestinal metaplasia, gastric dysplasia and human gastric carcinoma. The positive frequency of hTERT protein expression in human gastric carcinoma is significantly higher than that in gastric dysplasia, intestinal metaplasia and chronic atrophic gastritis ( P 0.05) , the positive frequency of hTERT protein expression in gastric dysplasia is significantly higher than that in intestinal metaplasia and chronic atrophic gastritis ( P 0.05) , and the positive frequency of hTERT protein expression in intestinal metaplasia is significantly higher than that in chronic atrophic gastritis ( P 0.05) .It takes on an increased tendency that the positive frequency of Bcl-2 protein expression in chronic atrophic gastritis, intestinal metaplasia, gastric dysplasia and human gastric carcinoma. The positive frequency of Bcl-2 protein expression in human gastric carcinoma is significantly higher than that in gastric dysplasia, intestinal metaplasia and chronic atrophic gastritis ( P 0.05) ,the positive frequency of Bcl-2 protein expression in gastric dysplasia is higher than that in chronic atrophic gastritis (P 0.05) and that in intestinal metaplasia (but P 0.05) ,the positive frequency of Bcl-2 protein expression in intestinal metaplasia is significantly higher than that in chronic atrophic gastritis ( P 0.05) . The positive frequence of hTERT protein expression in cases with Bcl-2 protein expression is significantly higher than that in cases without Bcl-2 protein expression (P 0.01) .Conclusion The results suggest that both the Bcl-2 expression and the activity of telomerase can function in gastric carcinoma and its precancerous lesions to promote arising and development of gastric carcinoma , and Bcl-2 protein expression may be an important role in activing telomerase.