2010•Unpublished venueRequires access
Expression and significance of hTERT protein and c-myc protein in human gastric cancer and precancerous lesion
Guoan Wang
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Abstract
Objective:To study the expression and significance of hTERT protein and c-myc protein in human gastric mucous membrance lesions and precancerous lesion.Methods: The expression of hTERT protein and c-myc protein in 50 chronic gastritis and 21 gastric carcinoma was studied by using immunohistochemical method.Results: The positive expression of hTERT protein and c-myc protein in human gastric carcinoma was significantly higher than in gastric dysplasia,intestinal metaplasia and chronic atrophic gastritis(P0.05).The positive expression of hTERT protein and c-myc protein in gastric dysplasia was significantly higher than in intestinal metaplasia and chronic atrophic gastritis(P0.05).The positive expression of hTERT protein and c-myc in intestinal metaplasia was significantly higher than that in chronic atrophic gastritis(P0.05).The positive expression of hTERT protein in patients with positive expression of c-myc protein was significantly higher than that in those without positive expression of c-myc protein(P0.01).Conclusion: Both c-myc expression and the activity of telomerase may play roles in gastric carcinoma by promoting pathogenesis and development of gastric carcinoma,and c-myc protein expression may play an important role in activing telomerase.