Expression and clinical significance of survivin and PTEN in specimens of cervical carcinoma

Objective:The purpose of this study is to examine the expression and the relationship of apoptosis inhibition factor survivin and carcinoma-inhibiting protein PTEN in cervical cancer and precancerous tissues.Methods:There were 93 patients with chronic cervicitis and cervical erosion of metaplasia(CCM),cervical intraepithelial neoplasia(CIN)and cervical carcinoma,and another 10 cases of normal cervical specimens were selected as the control.The expression levels of apoptosis inhibition factor survivin and carcinoma-inhibiting protein PTEN were tested by immunohistochemistry.Results:(1)From CCM to tumor progression,cervix cancer,survivin expression tends to increase ment(P0.01);the expression of PTEN tends to decrease ment(P0.01).(2)Survivin was related with the patients' infiltration,depth,clinical stages(P0.05),but not related with the patients' ages or histological grade of invasive carcinoma(P0.05).(3)The expression of survivin and PTEN was extremely negatively correlated in CIN and cervical carcinoma(P0.01)and highly related in cervical carcinoma.Conclusion:The abnormal high expression of survivin and abnormal low expression of PTEN in cervical carcinoma may be involved in the occurrence and development of cervical carcinoma,may be related with the cell apoptosis and proliferation,they occur in the early period of cervical carcinoma transformation,and higher levels of survivin and lower levels of PTEN may indicate infausta prognosis for patients with cervical carcinomas.