Relationship between Expressions of PTEN, COX-2 and Invasion, Metastasis in Cervix Carcinoma

Objective To investigate the expressions of PTEN and COX-2 in carcinoma of cervix, and the relationship between their expressions and invasion, metastasis. Methods The expression of PTEN and COX-2 were examined by immunohistochemistry SP method in 68 cases of cervical carcinoma tissue. Results The positive expression rate of PTEN in cervical carcinoma was markedly lower than that in normal cervical tissue, with statistical significance(P0.01), and there was significantly related with lymph nodal metastasis(P0.05). While the positive expression rate of COX-2 was significantly higher in cervical carcinoma than that in normal cervical tissue(P0.01), and there was remarkably positive correlated with lymph node metastasis(P0.05). In cervical carcinoma tissue, the expressions of PTEN and COX-2 were negatively correlated(P 0.05). Conclusions The abnormal expressions of PTEN and COX-2 are closely related with carcinogenesis, development and lymph node metastasis.They may have the synergism in the carcinogenesis and invasion, metastasis of cervical carcinoma.