The Comparative Investigation between Ziprasidone and Risperidone in the Treatment of Schizophrenia

Objective To explore the clinical efficacy and safety of ziprasidone and risperidone in the treatment of schizophrenia.Methods 60 patients cases met the CCMD-3 diagnosis of schizophrenia were randomly assigned to ziprasidone group(n=30) or risperidone group(n=30).The efficacy of patients were assessed with the positive symptoms and negative symptoms scale(PANSS),and the side efficacy was evaluated with treatment emergent symptom scale(TESS).Results After 8 weeks treatment,the marked improvement rate was 66.7% and effective rate was 86.7% in ziprasidone group,while 70% and 90% in risperidone group,and there were no significant differences between two groups(P0.05).After treatment,the two groups showed significant differences compared with the PANSS.Frequency of extrapyramidal reactions,weight gain,and menstrual changes in women were significantly less in ziprasidone group than in risperidone.Conclusion Ziprasidone was as effective as risperidone for the treatment of schizophrenia and has good compliance,fewer side effects.