The relevance of PTH,25(OH)D3,CT,bone metabolism indicator with BMD in 860 female

Objective:To study the relevance of PTH,25(OH)D3,CT,bone resorption markers CTX-1 and TRACP,bone formation markers BGP and BALP with the neck BMD in female. Methods:Enzyme immunoassay analyzer of Thermo company were used to detect PTH,25(OH)D3,CT,CTX-1,TRACP,BGP,BALP,and neck BMD was measured by Discovery-WA-type bone mineral density detector of the United States Hologic company.The results of 860 objects were divided into several groups according to the standard of 5-year-old age as a group SPSS 13.0 software was applied for statistical analysis. Results:The measure values of PTH,25(OH)D3 and CT had no differences in 35-50 age groups.The measure values of 25(OH)D3 began to decline after the age of 50,and 25(OH)D3 had positive relevance with BMD.The measure values of CT was decreased in the age groups from 65 to 79 years old,and was significant positive correlated with BMD.The CTX-1,TRACP had negative relevance with BMD and BGP,BALP had positive relevance with BMD in 35-45 age group.The BGP,BALP increased significantly and CTX-1,TRACP,BGP,BALP had negative relevance with BMD in 50-60 age group.BGP,BALP began to decline and had positive relevance with BMD,and CTX-1,TRACP had negative relevance with BMD after the age of 65. Conclusion:PTH,25(OH)D3,CT,CTX-1,TRACP,BGP,BALP are the important technical means for monitoring the level of bone metabolism and the diagnosis and differential diagnosis of osteoporosis.