Relevance of parathyroid hormone (PTH), vitamin 25(OH)D3, calcitonin (CT), bone metabolic markers, and bone mass density (BMD) in 860 female cases

OBJECTIVE: To study the relevance of PTH, 25(OH)D3, CT, bone resorption markers C-terminal telopeptide of type I (CTX-1), and tartrate-resistant acid phosphatase (TRACP), bone formation markers bone gla protein (BGP), bone alkaline phosphatase (BALP) with the femoral neck BMD in females. MATERIALS AND METHODS: PTH, 25(OH)D3, CT, CTX-1, TRACP, BGP, and BALP were detected by an enzyme immunoassay analyzer and femoral neck BMD were measured by a BMD detector. The results of 860 females were divided into several groups according to standard of five-year age intervals. SPSS 13.0 software was used for statistical analysis. RESULTS: The measured values of PTH, 25(OH) D3 and CT had no differences in 35-50 age group. The measured values of 25(OH) D3 began to decline after the age of 50, and 25(OH)D3 had positive relevance with BMD. The values of CT were decreased in the age groups from 65 to 79 years old, and were significant positive correlated with BMD. The CTX-1 and TRACP had negative relevance with BMD in 35-45 age group and BGP and BALP had positive relevance with BMD in 35-45 age group. The BGP, BALP increased significantly in 50-60 age group, and CTX-1, TRACP, BGP, and BALP had negative relevance with BMD in 50-60 age group. BGP and BALP began to decline and had positive relevance with BMD after the age of 65, and CTX-1 and TRACP had negative relevance with BMD after the age of 65. CONCLUSIONS: PTH, 25(OH)D3, CT, CTX-1, TRACP, BGP, and BALP were the important technical means for monitoring the level of bone metabolism and the diagnosis and differential diagnosis of osteoporosis.