Comparative analysis of rabeprazole and lansoprazole triple therapy in the treatment of Helicobacter pylori-positive peptic ulcer

Objective To compare the clinical efficacy of rabeprazole and lansoprazole triple therapy for Helicobacter pylori(Hp)-positive peptic ulcer.Methods Eighty-six Hp-positive peptic ulcer patients who were admitted into our hospital were randomly divided into two groups.The treatment group(n=44) received rabeprazole + amoxicillin + clarithromycin,and the control group(n=42) received lansoprazole + amoxicillin + clarithromycin.Endoscopy,rapid urease test and 14C breath test were conducted 4 weeks after medication was stopped.Ulcer healing and Hp eradication were observed.Results The cure rate,ulcer healing,and Hp eradication rate were higher in the treatment group than in the control group.The rate of Hp infection recurrence was significantly reduced,and there was low incidence of adverse reactions.Conclusion For the treatment of Hp-positive patients with peptic ulcer,the triple therapy of rabeprazole,amoxicillin,and clarithromycin can significantly improve the cure rate of ulcer healing and Hp eradication,reduce the recurrence rate of Hp infection with more safety.It is an ideal treatment scheme and is worth promoting.