Clinical effect of rabeprazole triple therapy on the treatment of Hp related peptic ulcer

Objective To explore the efficacy of rabeprazole triple therapy regimens in the treatment of Helicobacter pylori-related ulcer.Methods 68 cases with documented peptic ulcer and Hp infection by endoscopic examination and rapid urease test were randomized to receive rabeprazole or omeprazole-based triple therapy regimenss.The experimental group: Rabeprazole(Pollitt)10 mg,1 times/d×14 d,amoxycillin 1.0 g,2 times/d×7 d,clarithromycin 0.5 g,2 times/d×7d; and the Controlgroup:Omeprazole(Mather)20 mg,1 time/d×14 d,amoxycillin,clarithromycin were the same test group. All four weeks after the end of treatment,review of endoscopy and Hp,ulcer healing and Hp observation,as well as adverse reactions to eradicate the situation.Results The healing rate and the two groups was the total effective rate is similar between the test group and control group(P0.05).Hp eradication rate and the test group was 93.18%(31/34),the control group was 76.47%(26/34),and there were statistically significant differences(χ~2=7.58,P0.05) byχ~2 test between the two groups.Conclusion Compared with omeprazole-based triple therapy regimens,rabeprazole-based triple therapy regimens was better in the ulcer healing rate,symptomatic relief and Hp eradication rate.