Clinical observation on Rabeprazole triple therapy in treatment of peptic ulcer correlated with helicobacter pylori

Objective To observe the efficacy of Rabeprazole triple therapy and Omeprazole triple therapy in the treatment of peptic ulcer correlated with helicobacter pylori(HP).Methods Totally 150 cases of peptic ulcer were randomized into two groups: treatment group and control group.Rabeprazole triple therapy(Rabeprazole,Clarithromycin and Amoxicillin) was applied in treatment group while Omeprazole triple therapy(Omeprazole,Clarithromycin and Amoxicillin) was adopted in control group for one week.Ulcer curative rate,recurrence rate and HP removing rate were observed through endoscope and rapid urease test four week and half a year after the therapy completed.Results No statistical difference in HP removing rate(84% vs.81.33%) was observed between the two groups(P0.05),however,statistical differences were found in ulcer curative rate(94.67% vs.81.33%) and recurrence rate(7.69% vs.16.13%) between the two groups(P0.05).Conclusion Both Rabeprazole triple therapy and Omeprazole triple therapy can quickly alleviate the clinical symptom of peptic ulcer correlated with HP,but Rabeprazole triple therapy is more effective in raising ulcer curative rate and HP removing rate as well as reducing recurrence rate.