2012•Linchuang huicuiRequires access
Clinical value of serum ghrelin and pepsinogen in patients with chronic atropic gastritis and gastric cancer
Yong Jiang
Open publisher page 0 citations
Abstract
Objective To investigate the diagnostic value of serum pepsinogen Ⅰ/pepsinogen Ⅱ(PGⅠ/PGⅡ) and ghrelin in atrophy of gastric mucosa and gastric cancer,by testing serum PGⅠ/PGⅡ and ghrelin in patients with superficial gastritis,atrophic gastritis or gastric cancer.Methods Enzyme immunoassay was used to detect serum PGⅠ,PGⅡ and ghrelin.PGⅠ/PGⅡ was calculated,and the results were processed in statistical analysis.Results In atrophic gastritis or gastric cancer patients,PGⅠ/PGⅡ was respectively 9.14±1.80 and 7.50±2.06,which were significantly lower than that in superficial gastritis patients,11.55±2.29.Serum ghrelin in atrophic gastritis or gastric cancer patients was(18.59±8.19) μg/L and(17.10±7.13) μg/L,which were significantly lower than that in superficial gastritis patients,(26.08±9.15) μg/L.The difference had statistical significance.PGⅠ/PGⅡ was positively correlated with the change of ghrelin(r=0.668,P0.01).The area under the ROC curve of PGⅠ/PGⅡ in diagnosis of atrophic gastritis was 0.635,and that in diagnosis of gastric cancer was 0.811.The area under the ROC curve of ghrelin in diagnosis of atrophic gastritis was 0.680,and that in diagnosis of gastric cancer was 0.695.Conclusion PGⅠ/PGⅡ and serum ghrelin level could be used as targets in screening and diagnosing atrophic gastritis and gastric cancer.