The value of the joint detection of serum Pepsinogen and Gastrin-17 in the screening of atrophic gastritis and gastric cancer

Objective: To investigate the value of the levels of serum Pepsinogen( PG) and Gastrin-17( G-17) in the screening of atrophic gastritis and gastric cancer. Methods: Two hundred and seventy-eight patients undergone gastroscopy from August 2012 to October 2013 were divided into the chronic non-atrophic gastritis group( 105 cases),atrophic gastritis group( 42 cases),gastric cancer( 64 cases) and gastric ulcer group( 67 cases) according to the results of gastroscopy and histopathology. The levels of serum PGⅠ,PGⅡ and G-17 in all case were measured by enzyme-linked immunosorbent assay( ELISA),and the PGR( ratio of PGⅠ to PGⅡ) was calculated. Results: Compared with the chronic non-atrophic gastritis group,the PGⅠ level and PGR decreased significantly in atrophic gastritis and gastric cancer groups( P 0. 01),but for G-17,it increased significantly in the two groups( P 0. 01). Compared with the atrophic gastritis group,the PGⅠ level and PGR in gastric cancer group decreased significantly( P 0. 01),the difference of the G-17 level between the atrophic gastritis and gastric cancer groups was not statistically significant( P 0. 05). The PGⅠ level and PGR in advanced gastric cancer patients were significantly lower than those in early gastric cancer patients( P 0. 01),while the difference of G-17 level between them was not statistically significant( P 0. 05). Conclusions: The PGⅠ level and PGR decreasing and G-17 level increasing suggest the possible of atrophic gastritis and gastric cancer. The joint detection of serum Pepsinogen and Gastrin-17 is an important means in the screening of atrophic gastritis and gastric cancer,which can provide a positive reference for further gastroscopy.