A Study on the Relationship of Acute Myocardial Infarction and TH1/TH2 Response

Objective: To investigate the pathophysiologic significance of serum level changes of some cytokines in acute myocardial infarction(AMI).Methods: The serum levels of IFN-γ,TNF-α,TGF-β,and IL-4,IL-6,IL-10 in 27 cases of AMI and 29 healthy people(as control) were measured with a sensitive sandwich enzyme-linked immunosorbent assay(ELISA).Results:(1) Levels of IFN-γ were higher in control group than those in AMI group.Levels of TNFαin AMI group were significantly higher after treatment than before(P0.001).(2) Levels of IL-6 in AMI group were lower after treatment than before(P0.01),and were both higher than those of the controls(P0.05).TGF-β1 Levels in AMI group were lower than those of healthy control,and were higher after treatment than before the treatment.No significant difference was found among the levels of IL-4 and IL-10 in both groups.Conclusions: The acute seizure of myocardial infarction relates to immunological response,and might have a bias trend to TH2 response.