Changes of Plasma Levels of Cytokine Interleukin 6 in Patients before and after the Treatment for AMI and CSA

Objective: To study the role of interleukin 6 (IL 6) in the pathophysiological process of acute myocardial infarction (AMI) and coronary spastic angina (CSA). Methods: The plasma IL 6 levels in 27 cases of AMI, and 20 cases of CSA including 11 cases of unstable angina (UA) and 9 cases of stable angina (SA), were measured with enzyme linked immunosorbent assay (ELISA), before and after treatment for their diseases. The plasma IL 6 levels of 31 healthy people were measured as control. Results: The IL 6 levels were higher in AMI patients than those in healthy controls( P0 01 ). IL 6 levels in AMI patients before and after treatment did not show difference( P0 05 ). For CSA patients, the IL 6 level was higher in UA than in healthy controls( P0 05 ). but it’s not different in SA from that in healthy people( P0 05 ). The IL 6 levels were higher in UA than in SA( P0 05 ). And they were higher in AMI than in UA( P0 01 ). Conclusion: The results suggest that the levels of IL 6 significantly relate to the pathogenesis of AMI and CSA.[