ScholarLens Back to search
2001•Acta Academiae Medicinae JiangxiRequires access

Effect and Mechanism of Tumor Necrosis Factor on Hepatic Injury Rats

Ding Jian

Open publisher page 0 citations

Abstract

Objective: To study the effect and mechanism of tumor necrosis factor inducing hepatic injury. Methods: 24 male Sprague Dawley rats were randomly devided into normal saline control group (Ⅰ)and TNF group(Ⅱ). The rats in TNF group were inject with TNF of 1.6×10 6 u/kg through vein. ALT?AST?SOD, and MAD in serum at 0, 2, 4, and 8 hours after injection were determined. The liver tissues were observed with light and electron microscope at 8 hours. Results: (1) ALT and AST in TNF group increased significantly compared with those before injection ( P 0.05).Liver tissues were found damage, including hepatocellular degeneration and necrosis. (2) MDA of TNF group increased significantly but SOD of the group decreased significantly (both P 0.05). Conclusion:(1)TNF induces obviously hepatic injury;(2)Free radicals play an important role in TNF mediated cytotoxicity.

About this research paper

What this paper is about

Objective: To study the effect and mechanism of tumor necrosis factor inducing hepatic injury. Methods: 24 male Sprague Dawley rats were randomly devided into normal saline control group (Ⅰ)and TNF group(Ⅱ). The rats in TNF group were inject with TNF of 1.6×10 6 u/kg through vein. ALT?AST?SOD, and MAD in serum at 0, 2, 4, and 8 hours after injection were determined. The liver tissues were observed with light and electron microscope at 8 hours. Results: (1) ALT and AST in TNF group increased significantly compared with those before injection ( P 0.05).Liver tissues were found damage, including hepatocellular degeneration and necrosis. (2) MDA of TNF group increased significantly but SOD of the group decreased significantly (both P 0.05). Conclusion:(1)TNF induces obviously hepatic injury;(2)Free radicals play an important role in TNF mediated cytotoxicity.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective: To study the effect and mechanism of tumor necrosis factor inducing hepatic injury. Methods: 24 male Sprague Dawley rats were randomly devided into normal saline control group (Ⅰ)and TNF group(Ⅱ). The rats in TNF group were inject with TNF of 1.6×10 6 u/kg through vein. ALT?AST?SOD, and MAD in serum at 0, 2, 4, and 8 hours after injection were determined. The liver tissues were observed with light and electron microscope at 8 hours. Results: (1) ALT and AST in TNF group increased significantly compared with those before injection ( P 0.05).Liver tissues were found damage, including hepatocellular degeneration and necrosis. (2) MDA of TNF group increased significantly but SOD of the group decreased significantly (both P 0.05). Conclusion:(1)TNF induces obviously hepatic injury;(2)Free radicals play an important role in TNF mediated cytotoxicity.

Key concepts: Tumor necrosis factor alpha, Necrosis, Tumor necrosis factor α, Saline, Internal medicine, Endocrinology, Medicine, Liver injury

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source