Correlation between hepatic CT perfusion imaging and portal vein pressure in normal Beagles

Objective To evaluate the correlation between the parameters of spiral CT perfusion imaging and portal vein pressure in normal Beagles.Methods Twenty-four normal beagles were selected to receive hepatic spiral CT perfusion imaging.The parameters of hepatic perfusion,including blood flow(BF),blood volume(BV),mean transit time(MTT),hepatic arterial fraction(HAF),hepatic arterial perfusion(HAP),and portal venous perfusion(PVP),were calculated by the method of deconvolution.The portal vein pressure was measured by glass column method in laparotomy surgery three days after CT imaging.Results Portal vein pressure of the beagles were(13.57 ± 1.15)cmH2O.Portal vein pressure was negatively correlated with the BF and PVP,but was positively correlated with HAF.PVP was the most significant parameter that correlated with portal vein pressure(r =-0.764,P 0.05),and their linear regression equation was Y = 16.507-0.037X.Conclusion CT perfusion imaging is a new non-invasive and effective method for assessing portal vein pressure.