Experimental Study on the Effects of Prostaglandin E1 on Liver Haemodynamics Measured by Hepatic CT Perfusion

Objective:To investigate the role of CT perfusion in quantitative estimation of valid hepatic blood flow and effects of prostaglandin E1 on liver haemodynamics.Methods:Twenty-one healthy adult dogs were selected to undertake hepatic perfusion by 64-detector spiral CT(Toshiba Aquilion 64).The time-density curve of region of interest was drawn.The hepatic arterial infusion(HAI)and portal vein perfusion(PVP)were calculated by the means of deconvolution.Meanwhile the parameters of hepatic arterial flow and portal venous flow measured by electromagnetic flowmeter were converted to and HAI and PVP.Then the value measured by CT perfusion and electromagnetic flowmeter were compared and the accuracy of CT perfusion was calculated.After 5 μg alprostadil administration via small asphenous vein for 5 minutes,dynamic enhancement scanning was performed.The value of HAI and PVP pre-and post alprostadil injection were compared.Results:The hepatic artery flow,portal venous flow and total liver flow measured by CT perfusion were(145±35)ml·min-1,(611±161)ml·min-1,(755±179)ml·min-1,respectively.The hepatic artery flow,portal venous flow and total liver flow measured by electromagnetic flowmeter were(127±44)ml·min-1,(637±165)ml·min-1,(764±182)ml·min-1,respectively.The correlation coefficients of the three parameters measured by the two measurements were 0.671,0.828,and 0.899,respectively.The value of HAP,PVP and THBP after PGE1 administration was(0.22±0.19)ml·min-1·ml-1,(1.82±0.41)ml·min-1·ml-1 and(2.04±0.36)ml·min-1·ml-1 and there was significant difference between them when compared with the control group.Conclusion:Hepatic blood flow can be quantitatively estimated by CT perfusion and has the similar accuracy with electromagnetic flowmeter,which can effectively reflect liver hemodynamics state.Hepatic blood flow obviously increased after intravenous injection of PGE1,especially in PVP.