The relationship of the serum uric acid concentration and prognosis of patients with cerebral infarction

Objective To explore the relationship between the level of serum uric acid concentrations and prognosis of patients with cerebral infarction by detection of serum uric acid concentration. Methods The data of 70 cases of patients with acute cerebral infarction in our hospital from 2008 to 2011 were retrospectively analyzed and divided into normal uric acid group and high uric acid group. Results Serum uric acid of normal uric acid group was (327.3±76.4) μmol/L and that of high uric acid group was (478.5±94.5) μmol/L. Barthel score of normal uric acid group was (44.4±12.2)points before treatment and (78.5±14.9) points after treatment. Barthel score of normal uric acid group after treatment was significantly higher than it before treatment (P 0.05). Barthel score of high uric acid group was(22.1±13.8) points before treatment and (45.5±12.9) points after treatment. Barthel score of high uric acid group after treatment was significantly higher than it before treatment(P 0.05). The result of logistic regression analysis of multiple factors with the patient's discharge Barthel scores showed that serum uric acid level in patients with acute cerebral infarction was negatively correlated with discharged Barthel scores(r = -1.35, OR=0.27,P 0.05). The higher the level of serum uric acid was, the worse the prognosis of patients with cerebral infarction was. Conclusion Hyperuricemia is a risk factor for early poor prognosis in cerebral infarction and can be used as a reference to assess the prognostic indicators. The higher the level of serum uric acid is, the worse the prognosis is. To reduce the level of serum uric acid in the treatment of patients with cerebral infarction can improve the prognosis.