A Randomized Controlled Multicenter Clinical Trial on Tazarotene Gel Versus Calcipotriol Ointment in the Treatment of Plaque Psoriasis Vulgaris

OBJECTIVE: To evaluate the efficacy and safety of 0.05% tazarotene gel in the treatment of patients with plaque psoriasis vulgaris. METHODS: A randomized open labeled controlled multicenter clinical trial was conducted. Total 208 patients with plaque psoriasis were enrolled in present clinical study. Among them, 105 patients were topically treated with 0.05%tazarotene gel once daily. 103 patients were assessable for safety and 98 patients were assessable for efficacy. 103 patients patients were topically treated with 0.005% calcipotriol ointment twice daily, 101 patients were assessable for safety and efficacy. The duration of treatment was 12 weeks for both groups. RESULTS: The results showed that Total effective rate was 76.5% for tazarotene gel group, 77.2% for calcipotriol ointment group (P0.05). Local skin irritation was found in 12.6% in tazarotene gel group and 9.9% in calcipotriol ointment group (P0.05)respectively, no systemic adverse event was found in either groups. CONCLUSION: The present study suggest that 0.05% tazarotene gels were safe and effective in the treatment of plaque psoriasis vulgaris.