The Change of Serum SOD in Patients with Acute Cerebrovascular Disease and Its Significance

Objective To explore the change and significance of serum superoxide dismutase (SOD) in acute phase of cerebrovascular disease. Methods The concentrations of serum SOD in 92 patients with acute cerebrovascular disease from April 2011 to October 2011 in the Third Affiliated Hospital of Sun Yat-sen University were measured by pyrogallicacid oxidation method. The levels of serum SOD within 24 hours and after 3 ~ 7 days were compared with the control group. Results The level of serum SOD in patients with cerebrovascular disease before treatment was lower than that in control group (P 0.01). The serum SOD concentration in improvement group after treatment was higher than that before treatment (P 0.01). Serum SOD in not improvement group was nearly equal with the patients before treatment (P 0.05). Serum SOD in mild group was still lower than the control group (P 0.01). Serum SOD in not improvement group was lower than control group (P 0.01). Conclusions The change of the serum SOD level is closely related with the stage of the cerebrovascular disease. It can provide a useful index to judge the progress of the cerebrovascular disease and to decide the best opportunity to use free radical scavenger.