A Study of SOD and MDA Level Changes in Plasma and their Clinical Significance in the Patients with Ischemic Cerebrovascular Disease

Objective: To explore the relationship of superoxide dismutase (SOD) and malonic dialdehyde (MDA) with ischemic cerebrovascular disease. Methods: The plasma SOD and MDA concentrations of 47 patients with ischemic cerebrovascular disease were measured by xanthine oxidation method (for SOD) and thiobarbiturate method (for MDA) within 72 hours after their invasion (acute stage);among them 20 patients (as improvement group) were measured again in 3 weeks after their invasion.Meantime there were other 33 subjects as control group.Results:The plasma SOD concentration was significantly decreased in acute stage of patients than that in control group (P0 01) and the plasma MDA concentration of patients was significantly higher than that in control group (P0.01). The plasma SOD and MDA concentration in improvement group were nearly equal with control group (P0.05).The plasma MDA level of moderate hyponeuria integral group was a little higher than that in mild group (P0.05). Plasma SOD level in the sever hyponeuria integral group was significantly lower than that in mild group (P0 01) but their plasma MDA level was significantly higher than that in mild group (P0.01).Conclusion: The plasma SOD level significantly decreased and the MDA level significantly increased after acute ischemic cerebrovascular diceacse.This change was closely related with the state of illness. The plasma SOD and MDA concentrations tended to be normal when the disease improved.