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2006•Chinese Clinical OncologyRequires access

Relationship between the expression of cyclooxygenase-2 and MDR1/P-glycoprotein in breast cancer

Zhang Jing-chua

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Abstract

Objective:To study the expression of cyclooxygenase-2 (COX-2) and P-glycoprotein (P-gp) in breast cancer.Methods: Expression of COX-2 and P-gp was detected in 32 cases of breast cancer tissue by immunohistochemistry. Results: The positive COX-2 expression was 71.9% in breast cancer, and the positive P-gp was 46.9%. The expression of COX-2 in P-gp positive breast cancers was significantly higher than that in P-gp negative breast cancers. Conclusion: The expression of COX-2 was significantly correlated with P-glycoprotein. COX-2 might play a crucial role in mediation of multidrug-resistance (MDR) in breast cancer.

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What this paper is about

Objective:To study the expression of cyclooxygenase-2 (COX-2) and P-glycoprotein (P-gp) in breast cancer.Methods: Expression of COX-2 and P-gp was detected in 32 cases of breast cancer tissue by immunohistochemistry. Results: The positive COX-2 expression was 71.9% in breast cancer, and the positive P-gp was 46.9%. The expression of COX-2 in P-gp positive breast cancers was significantly higher than that in P-gp negative breast cancers. Conclusion: The expression of COX-2 was significantly correlated with P-glycoprotein. COX-2 might play a crucial role in mediation of multidrug-resistance (MDR) in breast cancer.

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Available abstract

Objective:To study the expression of cyclooxygenase-2 (COX-2) and P-glycoprotein (P-gp) in breast cancer.Methods: Expression of COX-2 and P-gp was detected in 32 cases of breast cancer tissue by immunohistochemistry. Results: The positive COX-2 expression was 71.9% in breast cancer, and the positive P-gp was 46.9%. The expression of COX-2 in P-gp positive breast cancers was significantly higher than that in P-gp negative breast cancers. Conclusion: The expression of COX-2 was significantly correlated with P-glycoprotein. COX-2 might play a crucial role in mediation of multidrug-resistance (MDR) in breast cancer.

Key concepts: Medicine, Breast cancer, P-glycoprotein, Immunohistochemistry, Cyclooxygenase, Internal medicine, Oncology, Multiple drug resistance

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